Neuroprotective activity of <i>Acanthus maderaspatensis</i> L. against colchicine induced Alzheimer’s disease rat model

Background Traditionally, the plants were used for various diseases and disorders, including neuronal disorders. The present study was designed to evaluate neuroprotective effect of Acanthus maderaspatensis L. against colchicine induced neurobehavioral biochemical changes in Alzheimer’s disease rat model. Method Neuroprotective activity carried out by on Sprague-Dawley rats. Test group animals administrated with ethanol extract at dose 200, 400 600mg/kg 28 days. behavioral parameters assessed using Morris water maze test, Digital actophotometer Plus performed Days 0, 7, 14 intracerebroventricular administration assessing cognitive gross activities all groups. Biochemical parameter such as lipid peroxidation, glutathione, superoxide dismutase, catalase, total thiols acetylcholinesterase histopathology brain tissue final day experiment. Result Ethanol shows a dependent significant decrease time latency (p<0.001) plus increase locomotor EAM treated compared control group. showed decreases peroxidation increased dismutase catalase glutathione level groups Conclusion In conclusion, suggests that (EAM) possesses impairment associated oxidative stress